| 第 35 卷第 3 期 |  | Vol. 35 No. 3 | | 2005 年 6 月 | Jun 2005 |
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所属栏目：其它
(S)-酮基布洛芬的制备 |
| 刘志雄; 李翔(湖北省化学研究院; 湖北武汉) |
| 摘 要：以(-)-葡辛胺为拆分剂,研究了(RS)-酮基布洛芬的拆分与(R)-酮基布洛芬的消旋;在异丙醇溶剂中成盐,以KOH碱解S-酮基布洛芬的ee值为99.5%,单轮拆分率达40%. |
| 关键词：S-酮基布洛芬; （-）-葡辛胺; 半量拆分; 消旋化 |
| 中图分类号：R971.1 文献标识码：A 文章编号：1009-9212(2005)03-0024-02 |
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| Preparation of (S)-Ketoprofen |
| LIU Zhi-xiong; LI Xiang（Hubei Research Institute of Chemistry; Wuhan 430074; China） |
| Abstract：The resolution of (RS)-Ketoprofen into (S)-Ketoprofen was found to be effective via the N-octyl D-glucamine . The result of this method showed that each resolution yield was 40% with high optical purity of over 99%. Racemization of (R)-Ketoprofen had been studied and gave good results. |
| Key words：（S）- Ketoprofen; N-octyl D-glucamine; Resolution; Racemization |
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收稿日期：2004-12-15
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