| 第 35 卷第 3 期 |  | Vol. 35 No. 3 | | 2005 年 6 月 | Jun 2005 |
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所属栏目：其它
1-溴-5-苯基-四氮唑的合成 |
| 魏先红; 何宝娟; 陈泳洲(湖北师范学院化学与环境工程系; 湖北黄石) |
| 摘 要：以苯甲腈、叠氮钠、溴等为原料,经偶合,溴化合成了1-溴-5-苯基四氮唑。研究了反应时间、反应温度、溶剂与反应物配比对产品收率的影响。实验表明:在n(苯甲腈)∶n(叠氮钠)=1∶1.1,1 mol NH4Cl催化,120℃下反应20 h可得到收率90%的5-苯基四氮唑。在n(5-苯基四氮唑)∶n(溴)∶n(氢氧化钠)=1∶0.97∶0.96,反应4 h,水作溶剂的条件下,可得到56.4%的1-溴-5-苯基四氮唑,两步反应后的总收率为49.1%。 |
| 关键词：1-溴-5-苯基-四氮唑; 5-苯基-四氮唑; 合成 |
| 中图分类号：O626.28 文献标识码：A 文章编号：1009-9212(2005)03-0011-02 |
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| Synthesis 1-Bromine -5-Phenyl-Tetrazole |
| WEI Xian-hong; HE Bao-juan; CHEN Yong-zhou（Hubei Normal University; Huangshi 435002; China） |
| Abstract：The product 1-Bromine -5-phenyl-tetrazole was synthesized from benzonitrile,Br_(2) and sodium azide by cyclization and bromization. The factors influencing the synthesis were discussed and the best reaction conditions were found out. The optimum conditions were as follow: molar ratio of benzonitrile to sodium azide was 1∶1.1, the catalyst adding was 1.0 mol NH_(4)Cl, the reaction temperature was 120 ℃, and reaction time was 20h, the yield of 5Phenyl-Tetrazole reached 90%; Molar ratio of 5-Phenyl-Tetrazole t... |
| Key words：1-bromine- 5-phenyl-tetrazole; 5-phenyl-tetrazole; Synthesis |
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收稿日期：2004-12-03
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