第 35 卷第 4 期 Vol. 35 No. 4 2005 年 8 月 Aug 2005

所属栏目：有机合成原料 1,7-庚二酸的合成研究

朱平华(淮海工学院化工系; 江苏连云港)

摘　要：以1,5-戊二醇,三溴化磷,氰化钾为原料,18-冠-6为催化剂合成1,7-庚二酸。通过正交实验给出优惠合成条件:反应时间4h,反应温度85℃,w(催化剂)=6%(相对于1,5-戊二醇),1,7-庚二酸的收率90%。

关键词：1; 7-庚二酸; 合成; 相转移催化剂

中图分类号：TQ225.147　　文献标识码：A　　文章编号：1009-9212(2005)04-0058-02

Synthesis of 1,7- Pimelic Acid

ZHU Ping-hua （Department of Chemical Engineering; Huaihai Insititute of Technology; Lianyungang 222005; China）

Abstract：1,7-pimelic acid was synthesized from 1,5-dihydorxypentane and phosphorus (III) bromide and potassium cyanide with 1,4,7,10,13,16-hexaoxacyclooctadecane as catalyst. Optimal synthesis conditions were investigated by experiments using an orthogonal design. Yield of 1,7- pimelic acid were 90% under the optimal conditions such as reaction time 4h,temperature 85℃ and amount of catalyst 6% (based on1,5-dihydorxyppentane).

Key words：1; 7-pimelic acid; synthesis; the phase transfer catalyst

收稿日期：2005-03-24

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