| 第 35 卷第 4 期 |  | Vol. 35 No. 4 | | 2005 年 8 月 | Aug 2005 |
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所属栏目：医药及中间体
新法合成4-羟基苯甘氨酸 |
| 伊汀; 朱春燕; 陈晓峰(上海宝钢化工有限公司) |
| 摘 要：对以焦化苯酚为原料,氨基甲酸铵为氨化剂合成4-羟基苯甘氨酸的体系进行了研究。考察了物料配比、反应温度、反应时间等主要因素对反应的影响,在原料配比为:1.4∶1,反应温度为50￣70℃,反应时间为8h,返入N2保护,得到的产品纯度>99%,反应易于控制,具有较高的应用价值。 |
| 关键词：4-羟基苯甘氨酸; 氨基甲酸铵; 合成 |
| 中图分类号：TQ246.3+7 文献标识码：A 文章编号：1009-9212(2005)04-0020-02 |
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| A New Synthetic Process of 4- hydroxyphenylglycine |
| YI Ting; ZHU Chun-yan; CHEN Xiao-feng （Shanghai BaoChem Co; Ltd. Shanghai; Shanghai 200942; China） |
| Abstract：A new method for synthesis of 4-hydroxyphenylglycine was developed by amination in the presence of carbamic ammonium. Main factors influencing reaction were experimented.The optimum reactic condition was as follows:the ratio of phenol and is 1.4∶1(mol) temperature 50~70℃ reaction time 8 h.The purity of 4-hydroxyphenylglycine reached 99%,and the reaction conditions were easily controlled, which made it more suitable for industrial process. |
| Key words：4-hydroxyphenylglycine; carbamic ammonium; synthesis |
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收稿日期：2005-03-06
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