| 第 35 卷第 4 期 |  | Vol. 35 No. 4 | | 2005 年 8 月 | Aug 2005 |
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所属栏目：医药及中间体
N-乙基-2,3-二氧代哌嗪的合成 |
| 许建帼; 谢建伟; 吴敏; 邵丽莉(浙江工业大学浙西分校化工系; 浙江巨化技术中心; 浙江衢州) |
| 摘 要：以N-乙基乙二胺和草酸二乙酯为原料,在氯化胺催化作用下脱醇缩合得N-乙基-2,3-二氧代哌嗪。实验研究了反应物摩尔配比、反应时间、反应温度、催化剂用量等对N-乙基-2,3-二氧代哌嗪收率影响,得出了优惠工艺条件:催化剂用量为N-乙基乙二胺质量的1.5%,原料草酸二乙醇与N-乙基乙二胺摩尔比为1.02∶1,反应温度为20℃,乙酸用量200mL。总收率达到85%。 |
| 关键词：N-乙基乙二胺; N-乙基-2; 3-二氧代哌嗪; 哌拉西林 |
| 中图分类号：TQ252 文献标识码：A 文章编号：1009-9212(2005)04-0018-02 |
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| Synthesis of N-ethyl-2,3-dioxopiperazine |
| XU Jian-guo1; XIE Jian-wei 1; WU Ming2; SHAO Li-li2 （1.Department of Chemical Enginering; West Branch of Zhejiang Industry University; Quzhou 324006; China; 2.Juhua Group Technology Center; Quzhou 324004; China） |
| Abstract：N-ethyl-2,3-dioxopiperazine was synthesized from N-ethylethylenediamine and diethyl ethanedioate by condensation reaction with catalyst ammonia chloride .The effects of mole ratios , reaction time, temperature and the amount of catalyst on the yields of N-ethyl-2,3-dioxopiperazine were investigated .The optimal condition was as follows:w(cat)=1.5%(N-alkylethylenediamin),n(diethylethanedioate):n(N-alkylethylenediamine)=1.02∶1,reaction temperature 20℃,ethanol zooml,The yield of N-ethy1-2,3-dioxopipevazine was... |
| Key words：N-ethyl-2; 3- dioxopiperazine; N-alkylethylenediamine; Piperacillin |
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收稿日期：2005-03-02
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