| 第 35 卷第 5 期 |  | Vol. 35 No. 5 | | 2005 年 10 月 | Oct 2005 |
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所属栏目：有机合成原料
原位氧化氯化合成3-氯丁酮 |
| 钟文周; 尹笃林; 徐琼; 王季惠; 唐迪(湖南师范大学精细催化合成研究所教育部化学生物学及中药分析重点实验室; 湖南长沙) |
| 摘 要：利用盐酸-过氧化氢作反应物,通过原位氯化反应合成3-氯丁酮。考察了原料配 比、反应时间、反应温度、及金属盐的加入对反应结果的影响。以CuCl2作催化剂,丁酮、盐酸、过氧 化氢的摩尔配比为2∶1∶1．3时,回流温度下反应5h,丁酮转化率为52．43％,3-氯丁酮选择性 达76％,分馏得到的产品的纯度98％以上。 |
| 关键词：氧化氯化; 盐酸-过氧化氢; 3-氯丁酮 |
| 中图分类号：TQ224.5 文献标识码：A 文章编号：1009-9212(2005)05-0032-03 |
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| Synthesis of 3-chloro-2-butanone by oxidation-chlorination in situ |
| ZHONG Wen-zhou; YIN Du-lin; XU Qiong; WANG Ji-hui; TANG Di Institute of Fine Catalysis and Synthesis; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research; Hunan Normal University; Changsha 410081; China |
| Abstract：3-chloro-2-butanone was synthesized by chlorination in situ with HC1-H2O2. The influences of reaction conditions such as mole ratio, reaction time, reaction temperature and some metal salts were examined in detail. The optimum preparation conditions were CuCl2 as catalyst, n(butanone):n(HCl):n(H2O2)=2:l:1.3, reaction temperature 78℃ and reaction time is 5h. the conversion of butanone amount to 52.43%, the selectivity of 3-chloro-2-butanone is over 76% and its purity is over 98%. |
| Key words：oxidation-chlorination; HCl-H2O2; 3-chloro-2-butanone |
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收稿日期：2005-06-30
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