| 第 35 卷第 5 期 |  | Vol. 35 No. 5 | | 2005 年 10 月 | Oct 2005 |
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所属栏目：医药及中间体
3,4-二甲氧基苯胺的合成 |
| 裘炜杰; 林军(杭州电化集团股份有限公司; 浙江杭州) |
| 摘 要：以3,4-二甲氧基苯为原料。在0-5℃低温条件下,以硝酸和硫酸按比例配成的混酸进 行硝化,反应结束后过滤得到3,4-二甲氧基硝基苯,该步反应的收率有97％。然后以乙醇为溶剂, 雷尼镍为催化剂,在1．6 MPa的氢气压力下,于高压釜中100℃条件下通过催化加氢将3,4-二甲氧 基硝基苯还原为3,4-二甲氧基苯胺。该反应的收率达到90％以上,纯度达到98％以上。 |
| 关键词：3; 4-二甲氧基苯胺; 2-氯-4-氨基-6; 7-二甲氧基喹唑啉; 催化加氢; 邻二甲氧基苯 |
| 中图分类号：TQ246.3 文献标识码：A 文章编号：1009-9212(2005)05-0028-02 |
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| Synthesis of 3,4-Dimethoxyaniline |
| QW Wei-jie; LIN Jun Hangzhou Electrochemical Group Ltd. Co.; Hangzhou 310053; China |
| Abstract：3,4-Dimethoxyaniline was prepared with 3, 4-dimethoxybenzene. The 3, 4-dimethoxybenzene was nitrated by mixed acid of HNO3-H2SO4 under the reaction temperature of 0-5℃. 3,4-dimethoxynitroben-zene was obtained by filtration, and its yield reached over 97%. 3, 4-Dimethoxynitrobenzene was dissolved in ethanol and reduced to the product 3,4-dimethoxyaniline using Raney-Ni as catalyst under the hydrogen pressure of 1.6 MPa in an autoclave (100℃). The yield and purity of 3, 4-dimethoxyanline was up to 90% and 98%... |
| Key words：3; 4-Dimethoxyaniline; 4-amino-2-chloro-6; 7-dimethoxy quinazoline; Catalytic hydrogen-ation; 4-dimethoxynitrobenzene; Synthesis |
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收稿日期：2005-05-28
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