| 第 35 卷第 5 期 |  | Vol. 35 No. 5 | | 2005 年 10 月 | Oct 2005 |
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所属栏目：专论与综述
吲哒帕胺的合成进展 |
| 徐志; 李翔; 邓家伦; 余丹(湖北省化学研究院; 湖北武汉) |
| 摘 要：简要概述了吲哒帕胺在医学上的研制、药用价值和市场应用情况及前景;介绍了吲哒 帕胺的物理性质,详细综述了以2,3-二氢-2-甲基-1H-吲哚和4-氯-3-磺胺基苯甲酰氯为 原料的合成方法和工艺,分析了其优点和缺点。 |
| 关键词：吲哒帕胺; 2; 3-二氢-2-甲基-1H-吲哚; 4-氯-3-磺胺基苯甲酰氯 |
| 中图分类号：TQ251.3 文献标识码：A 文章编号：1009-9212(2005)05-0010-03 |
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| The Development of Synthesis Indapamide |
| XU Zhi; LI Xiang; DENG Jia-lun; YU Dan Hubei Research Institute of Chemistry; Wuhan 430074; China |
| Abstract：The preparation, application and foreground of indapamide in medicine are summarized.The physical character is also introduced. Some synthesis processes of indapamide from 2?-dihydro-2-methyl-lH-indole and 4-chloro-3-sulfamoyl benzoylchloride are reviewed in detail, and their advantage and disadvantage are compared. |
| Key words：Indapamide; 2; 3-dihydro-2-rnethyl-lH-indole; 4-chloro-3-sulfamoyl benzoylchloride; Synthesis |
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收稿日期：2005-05-02
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