第 35 卷第 5 期 Vol. 35 No. 5 2005 年 10 月 Oct 2005

所属栏目：专论与综述 位阻型硅烷化试剂在药物合成中的研究与应用

邓锋杰; 陈萍华; 温远庆; 蒋华麟(南昌大学化学系; 南昌航空工业学院环化系; 江西南昌)

摘　要：综述了位阻型硅烷化试剂的特点、保护原理和应用。就其在保护含杂原子的有机官能 团方面讨论了对羟基、羧基、羰基及胺基等的保护和去保护条件及其在药物合成中的应用。并对位 阻型硅烷化试剂的发展趋势进行展望。

关键词：位阻型; 氯硅烷; 保护基团; 药物合成; 选择性

中图分类号：O662 TQ46 TQ61　　文献标识码：A　　文章编号：1009-9212(2005)05-0006-04

Application of Organosilan as a Protective Reagent in the Synthesis of Pharmaceuticals

DENG Feng-jie; CHEN Ping-hua; WEN Yuan-qing; JIANG Hua-lin Department of Chemistry; Nanchang University. Nanchang 330047. China; Department of Enviroment and Chemistry; Nanchang Aviation Industry University; Nanchang 330034; China

Abstract：The characteristics, protective principle and application of Sterically hindered silane blocking agents were reviewed. Organochlorosilane is widely used in the protection of organic functional groups involving hetero atoms, such as hydroxyl, carboxyl, carbonyl, amino group and so on .The conditions of protection and deprotection and the application development in the synthesis of pharmaceuticals are given in the article. Its trend of development is viewed in this article.

Key words：Sterically hindered; Organochlorosilane; protective group; synthesis of pharmaceuticals; selective

基金项目：江西省自然科学基金资助项目(No.0520038)

收稿日期：2005-08-15

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