第 35 卷第 5 期 Vol. 35 No. 5 2005 年 10 月 Oct 2005

所属栏目：专论与综述 喹诺酮类药物的研究进展

陈超森; 曾卓; 熊淑群(华南师范大学化学与环境学院; 广东广州)

摘　要：在喹诺酮类药物基本结构的基础上,综述了以不同的基团取代喹诺酮环上的不同位置 时,对此类药物的抗菌活性及药代动力学性质的影响;介绍了第四代新品种西他沙星的合成方法。

关键词：喹诺酮; 结构改造; 抗茵; 抗生素; 西他沙星

中图分类号：TQ253.2　　文献标识码：A　　文章编号：1009-9212(2005)05-0001-05

The Research Development of the Fluoroquinolone Antibacterials

CHEN Chao-sen; ZENG Zhuo; XIONG Shu-qun Chemistry and Environment school of South China Normal University ?Guangzhou 510631China

Abstract：Antibacterial activity and pharmokinetics of quinolone compounds substituted with different substituted groups at different substituted positions were reviewed based on the basic structure of quinolone , and the synthesis method of the fourth generation quinolone product sitafloxacin was introduced.

Key words：quinolone; structure modification: antibiotic activity; synthesis; sitafloxacin

基金项目：广东省华南师范大学科研资助项目(No.670098)

收稿日期：2005-08-15

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