| 第 35 卷第 6 期 |  | Vol. 35 No. 6 | | 2005 年 12 月 | Dec 2005 |
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所属栏目：有机合成原料
相转移催化合成2,2-二羟甲基丙酸(DMPA)的研究 |
| 赵进; 黄祖良; 莫长姣; 陈洁(右江民族医学院化学教研室; 广西百色) |
| 摘 要：以甲醛和丙醛为原料,在相转移催化作用下经羟醛缩合及氧化反应合成了2,2一二羟甲基丙酸(DMBA)。缩合反应在30℃,n(甲醛)/n(丙醛)=2.2,催化剂为十六烷基三甲基溴化铵(HDTMA),用Na2CO3和Na0H的混合碱调pH=9,反应2h。反应后立即加盐酸中和调pH=5;氧化反应在70℃、反应时间2.5h。反应产物的结构用红外光谱(IR)表征。 |
| 关键词：2; 2一二羟甲基丙醛; 2一二羟甲基丙酸; 相转移催化反应; 缩合反应; 氧化反应 |
| 中图分类号：TQ225.12+3 文献标识码：A 文章编号：1009-9212(2005)06-0044-03 |
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| Synthesis of 2,2-dimethylolbutyric acid |
| ZHAO Jin; HUANG Zu-liang; MO Changjiao; CHEN Jie（Department of Chemistry; You jiang Medical College for Nationlities; Baise 533000; China） |
| Abstract：Using phase transfer catalyst,2,2-dimethylolbutyric acid was prepared by the aldol condensation and oxidation from formaldehyde and propionaldehyde.The most suitable technological conditions for the aldol condensation were as follows: phase transfer catalyst was HDTMAB;molar ratio n(formaldehyde)∶ n(propionaldehyde)=2.2∶1;pH=10;reaction temperature 30℃,and reaction time 2.0 h.The most suitable technological conditions for the oxidation were as follows: pH =4;reaction temperature 70℃,and reaction time 2.5h.T... |
| Key words：2; 2-dimethylolbutyric acid; phase transfer catalytic reaction; aldol condensation |
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收稿日期：2005-09-10
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