第 36 卷第 1 期 Vol. 36 No. 1 2006 年 2 月 Feb 2006

所属栏目：农药及中间体 2-氯-4-(4-氯苯氧基)-苯乙酮的制备

高桂祥; 徐志远; 王志军(江阴暨阳医药化工有限公司; 江苏江阴)

摘　要：叙述了新型农用杀菌剂恶醚唑中间体-2-氯-4-(4-氯苯氧基)-苯乙酮的合成工艺,该工艺以对氯苯酚和2,4-二氯苯乙酮为原料,在铜粉催化剂催化下进行缩合得到,反应收率为71.4%。研究证明该工艺收率高、操作简单、成本低,适合大规模工业化生产。

关键词：2-氯-4-（4-氯苯氧基）-苯乙酮; 恶醚唑; 合成

中图分类号：O642　　文献标识码：A　　文章编号：1009-9212(2006)01-0043-02

Synthesis of 2-chloro-4-(4-chlorophenoxy)-acetophenone

GAO Gui-xiang; XU Zhi-yuan; WANG Zhi-jun（Jiangyin Jiyang Medical Chemical Co.; Ltd; Jiangyin 214445; China）

Abstract：The synthesis process of 2-Chloro-4-(4-chlorophenoxy)-acetophene that was a new important intermediate of difenoconazole was described.p-Chlorophenol and 2,4-dichloroacetophenene under the catalysis of copper was condensed to give the product,and the total yield was 71.4%.This process can meet the industrialized production due to the fact that the method had high yield,easy operation and low cost.

Key words：2-Chloro-4-（4-chlorophenoxy）-aectophenone; Difenoconazole; Synthesis

收稿日期：2005-09-26

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