| 第 36 卷第 1 期 |  | Vol. 36 No. 1 | | 2006 年 2 月 | Feb 2006 |
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所属栏目：医药及中间体
6-氯咪唑并[1,2-b]哒嗪氢解脱卤反应动力学研究 |
| 王首英; 孙成辉; 高世豪; 赵信岐(北京理工大学材料科学与工程学院) |
| 摘 要：采用Pd/C催化剂在排除扩散影响的条件下,研究了常压下6-氯咪唑并[1,2-b]哒嗪氢解脱卤合成咪唑并[1,2-b]哒嗪的反应动力学,通过空白试验消除催化剂及溶剂对吸氢量的影响,以吸氢量来表征反应程度。试验测定了反应温度、pH值对反应速率的影响。研究结果表明,在试验条件下,6-氯咪唑并[1,2-b]哒嗪氢解脱卤反应对6-氯咪唑并[1,2-b]哒嗪表现为零级,反应表观活化能为44.8kJ/mol,指前因子为7.68×104mol.L-1.min-1。pH值为8时有利于反应进行。 |
| 关键词：反应动力学; 6-氯咪唑并[1; 2-b]哒嗪; 氢解; 脱卤 |
| 中图分类号：O642 文献标识码：A 文章编号：1009-9212(2006)01-0034-04 |
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| Kinetics of Hydrogenolysis Dehalogen of 6-Chloro-imidazo pyridazin |
| WANG Shou-ying; SUN Cheng-hui; GAO Shi-hao; ZHAO Xin-qi（School of Materials Science and Engineering; Beijing Institute of Technology; Beijing 100081; China） |
| Abstract：The reaction kinetics of synthesis of imidazopyridazine by hydrogenolysis of 6-chloro-imidazopyridazine was studied over Pd/C catalyst in an atmosphere of hydrogen.Both internal and external diffusions' effects were eliminated by stirring adequately.The effects of catalyst and solvent were eliminated by the experiments without adding substrate.The changes of the absorption amount of hydrogen with reaction time were measured to monitor the reaction extent.Results showed that the reaction was the zero-order w... |
| Key words：reaction kinetics; 6-chloro-imidazo[1; 2-b]pyridazine; hydrogenolysis; dehalogen |
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收稿日期：2005-10-20
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