| 第 36 卷第 2 期 |  | Vol. 36 No. 2 | | 2006 年 4 月 | Apr 2006 |
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所属栏目：医药及中间体
5-溴乙酰基水杨酰胺的制备 |
| 徐娟娟; 胡艾希; 王宇; 罗成礼(湖南大学化学化工学院; 湖南长沙) |
| 摘 要：5-溴乙酰基水杨酰胺是一种非常重要的医药与农药中间体。选择溴在乙酸溶剂中,5-乙酰基水杨酰胺溴化。当反应物n(5-乙酰基水杨酰胺)∶n(溴)=1∶1.05,5℃反应12h,可高选择性得到5-溴乙酰基水杨酰胺,收率93.2%。 |
| 关键词：α-溴化反应; 5-溴乙酰基水杨酰胺; 5-乙酰基水杨酰胺 |
| 中图分类号：TQ225.26+1 文献标识码：A 文章编号：1009-9212(2006)02-0032-02 |
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| Synthesis of 5-(Bromoacetyl) salicylamide |
| XU Juan-juan; HU Ai-xi*; WANG Yu; LUO Cheng-li（College of Chemistry and Chemical Engineering; Hunan University; Changsha 410082; China） |
| Abstract：5-(Bromoacetyl)salicylamide is an important intermediate of medicine and pesticide. 5-Acetyl salicylamide was brominated by bromine to give 5-(bromoacetyl)-salicylamide in high selectivity. The yield was 93.2% when the molar ratio of 5-acetyl salicylamide to bromine was 1 ∶ 1.05 at 5 ℃ for 12 h. |
| Key words：α-bromination; 5-（bromoacetyl）salicylamide; 5-acetyl salicylamide |
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收稿日期：2005-12-02
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