| 第 36 卷第 2 期 |  | Vol. 36 No. 2 | | 2006 年 4 月 | Apr 2006 |
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所属栏目：农药及中间体
R(+)对羟基苯氧基丙酸炔丙酯的合成 |
| 雷子蕙; 廖道华; 曹伟锋(华东理工大学制药工程系) |
| 摘 要：报道了合成超高效除草剂炔草酯的中间体R(+)对羟基苯氧基丙酸炔丙酯的方法。以(S)-(-)乳酸甲酯为原料,先与对甲苯磺酰氯反应制备S-对甲苯磺酰乳酸甲酯,再与对苯二酚和丙炔醇反应,制备R(+)对羟基苯氧基丙酸炔丙酯,总收率76%。旋光度为[α]2D5=+37.5。 |
| 关键词：除草剂; 炔草酯; R（+）对羟基苯氧基丙酸炔丙酯; （S）-（-）乳酸甲酯 |
| 中图分类号：TQ225.24 文献标识码：A 文章编号：1009-9212(2006)02-0029-03 |
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| Synthesis of R(+)-2-(4-Hydroxyphenoxy)propionic Acid Propynyl Ester |
| LEI Zi-hui; LIAO Dao-hua; CAO Wei-feng（Pharmaceutical Department of East China University of Science and Technology; Shanghai 200237; China） |
| Abstract：R(+)-2-(4-hydroxyphenoxy)propionic acid propynyl ester is an important intermediates of herbicide R-clodinafop-propargyl. A new method for synthesizing R(+)-2-(4-hydroxyphenoxy) propionic acid propynyl ester is reported in the paper. The starting material S-methyl lactate was condensed with p-toluenesulfonyl chloride to give L-methyl p-toluenesulfonyl lactate,and L-methyl p-toluenesulfonyl lactate reacted with hydroquinone and propargyl alcohol to give the target product R(+)-2-(4-hydroxyphenoxy) propionic ... |
| Key words：herbicide; R（+）-clodinafop-propargyl; R（+）-2-（4-hydroxyphenoxy）propionic acid propynyl ester; S-methyl lactate |
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收稿日期：2005-11-10
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