| 第 36 卷第 2 期 |  | Vol. 36 No. 2 | | 2006 年 4 月 | Apr 2006 |
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所属栏目：农药及中间体
5-氯-2,3-二氢-1-茚酮的合成研究 |
| 曾文平; 陈明; 张文杰; 余蔚蔚(湖南化工研究院; 湖南长沙) |
| 摘 要：以3-氯丙酰氯、氯苯、三氯化铝、浓硫酸为原料合成5-氯-2,3-二氢-1-茚酮,对影响反应的主要因素进行了研究,优化了条件,优化后的反应条件为:氯代酮合成:n(三氯化铝)∶n(氯苯)∶n(3-氯丙酰氯)=1.1∶4∶1,滴加温度为5℃,滴加时间2h,保温温度60℃,保温时间3h;5-氯茚酮合成:搅拌速度小于100r/min,n(H2SO4)∶n(氯代酮)=36.8∶1,滴加时间4h,溶剂为石油醚(90-120℃)。此工艺原料价廉易得,产品纯度高,总收率达50.6%,产品纯度达98%。 |
| 关键词：5-氯-2; 3-二氢-1-茚酮; 3-氯丙酰氯; 3-氯-1-（4-氯苯基）-1-丙酮; 合成 |
| 中图分类号：TQ244.3 文献标识码：A 文章编号：1009-9212(2006)02-0026-03 |
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| Synthesis of 5-Chloro-2,3-dihydro-1H-inden-1-one |
| ZENG Wen-ping; CHEN Ming; ZHANG Wen-jie; YU Wei-wei（Hunan Research Institute of Chemical Industry; Chang sha 410007; China） |
| Abstract：5-Chloro-2,3-dihydro-1H-inden-1-one was synthesized from 3-chloropropionyl chloride,chlorobenzene,aluminium chloride and sulfuric acid, the major influences factors on this reactions were studied, the reaction condition was optimized. The optimum conditions: 3-ch-loro-1-(4-chlorphenyl)-1-propanone:n(aluminium chloride) ∶ n(chlorobenzene) ∶ n(3-chloropro-pionyl chloride)=1.1 ∶ 4 ∶ 1, drop temperature was 5 ℃,drop time was 2 h,the reaction proceeded 60 ℃ for 3 h;5-chloro-2,3-dihydro-1H-inden-1-one ∶ n(sulfuri... |
| Key words：5-chloro-2; 3-dihydro-1H-inden-1-one; 3-chloropropionyl chloride; 3-chloro-1-（4-chlorphenyl）-1-propanone; synthesis |
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收稿日期：2006-01-09
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