| 第 36 卷第 2 期 |  | Vol. 36 No. 2 | | 2006 年 4 月 | Apr 2006 |
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所属栏目：专论与综述
不对称催化反应合成手性药物的研究进展 |
| 郭莉娜; 侯仲轲; 陈灿; 黄明智(华中师范大学化学学院; 湖南化工研究院药物研究所; 湖南化工研究院; 湖北武汉; 湖南长沙) |
| 摘 要：综述了不对称催化反应在手性药物合成中的应用,包括不对称催化氢化、不对称催化氧化、不对称催化环丙烷化、不对称催化羰基化和羰基的不对称催化还原。介绍了L-多巴、(S)-萘普生、薄荷醇、(S)-心得安、(S)-阿替洛尔、二肽抑制剂Cilastatin、氟西汀、布洛芬的合成工艺和Sharpless环氧化(AE反应)、不对称双羟基化(AD反应)、不对称羟氨化(AA反应)三种典型的不对称催化氧化反应。展望了不对称催化反应在手性药物合成中的发展方向。 |
| 关键词：手性药物; 不对称催化; 研究进展 |
| 中图分类号：O643.32 文献标识码：A 文章编号：1009-9212(2006)02-0001-04 |
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| Progress on Asymmetry Catalytic Reactions to Synthesis of Chiral Drug |
| GUO Li-na;HOU Zhong-ke;CHEN Can2;HUANG Ming-zhi(Department of Chemistry; Central China Normal University; Wuhan 430079; China; 2. Hunan Research Institute of Materia Medica; Changsha 410007; 3. Hunan Research Iustitute of Chemical Iudustry; China） |
| Abstract：The application of asymmetry catalytic reactions to synthesis of chiral drug such as asymmetry catalytic hydrogenation,oxidation,cyclopropanation,carbonylation and asymmetry catalytic reduction of carbonyl was reviewed. The synthesis methods of Levodopa,(S)-naproxen, 1-menthol,(S)-propranol,(S)-atenolol, cilastatin,fluoxetine,ibuprofen and three typical asymmetry catalytic oxidations such as Sharpless epoxidation,dihydroxylation and hydroxyamination were introduced. The trend of development of asymmetry cat... |
| Key words：chiral drug; asymmetric catalysis; progress |
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收稿日期：2005-12-10
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