| 第 36 卷第 3 期 |  | Vol. 36 No. 3 | | 2006 年 6 月 | Jun 2006 |
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所属栏目：农药及中间体
利用Mitsunobu反应合成芳基吡啶烷基醚 |
| 唐子龙(湖南科技大学化学化工学院; 湖南湘潭) |
| 摘 要：在室温下,以取代苯酚1a-b和吡啶烷基醇2a-d为原料通过Mitsunobu反应合成了相应的芳基吡啶烷基醚,反应收率为45%￣70%,反应物2和1之比为1.11∶(摩尔比)。结果表明当酚的6-位取代基为甲氧基时,产物的收率比6-位上没有取代基时的收率高;溶剂对反应收率的影响不大。并用1H NMR、13C NMR和MS等对产物的结构进行了测定。 |
| 关键词：醚; Mitsunobu反应; 合成 |
| 中图分类号：TQ223.2+4 文献标识码：A 文章编号：1009-9212(2006)03-0023-05 |
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| Synthesis of Aryl Pyridylalkyl Ethers by Mitsunobu Reaction |
| TANG Zi-long1; 2（1.School of Chemistry and Chemical Engineering; Hunan University of Science and Technology; Xiangtan 411201; China; 2.Faculty of Pharmacy; University of Paris-sud; 5; rue Jean-Baptiste Clement 92296 Chatenay-Malabry Cedex; France） |
| Abstract：A few of aryl pyridylalkyl ethers were synthesized by Mitsunobu reaction from substituted phenols 1a-b and pyridyl alcohols 2a-e at room temperature in 45%~70% yields.The ratio of 2 to 1 is 1.1 ∶ 1(mol/mol).The yield of the reaction of 2-iodo-6-phenol was higher than those obtained with 2-iodo-phenol,and the solvent has little effect on the yield of the reaction.The structure of the products were assigned with 1H NMR?13C NMR and MS. |
| Key words：ether; Mitsunobu reaction; synthesis |
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收稿日期：2006-03-23
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