| 第 36 卷第 3 期 |  | Vol. 36 No. 3 | | 2006 年 6 月 | Jun 2006 |
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所属栏目：医药及中间体
4-氯丁酰氯的合成研究 |
| 牛宇岚; 李敏; 段海龙(中北大学分校化学工程系; 山西太原) |
| 摘 要：以-γ丁内酯为原料、无水氯化锌作催化剂、氯化亚砜做氯化剂进行开环氯化合成4-氯丁酰氯。对该氯化反应原理进行了阐述,考察了影响反应的主要因素。优化工艺条件为:在55℃加热搅拌反应22h,催化剂用量3%～5%,收率82.7%。 |
| 关键词：-γ丁内酯; 4-氯丁酰氯; 氯化 |
| 中图分类号：TQ225.22 文献标识码：A 文章编号：1009-9212(2006)03-0021-02 |
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| Synthesis of 4-Chlorobutyryl Chloride |
| NIU Yu-lan; LI Ming; DUAN Hai-long（Department of Chemical Engineering; College of NorthChina Institute of Technology; Taiyuan 030008; China） |
| Abstract：The synthesis of 4-chlorobutyryl chloride was described using γ-butyroctone as material,anhydrous zinc chloride as the catalyst and thionyl chloride as chloridum.The reaction principle is expounded,and the main factors affecting the reaction are investigated.Optimal conditions were obtained as follow:reaction temperature is 55℃,reaction time 22 h and percent amount of catalyst 3%~5%.The yield of the product is 82.7% under the optimal conditions. |
| Key words：γ-Butyroctone; 4-Chlorobutyryl chloride; Chlorination |
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收稿日期：2006-01-13
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