| 第 36 卷第 3 期 |  | Vol. 36 No. 3 | | 2006 年 6 月 | Jun 2006 |
|
所属栏目：医药及中间体
那格列奈的合成工艺研究 |
| 邓燕; 蒋欢妹; 谢维跃; 陶德良(湖南工业大学绿色包装与生物纳米技术应用重点实验室; 湖南轻工研究院; 湖南株洲; 湖南长沙) |
| 摘 要：对那格列奈的生产工艺中的反应时间、温度、试剂的选择等进行探索、改进,选用对异丙基苯甲酸为起始原料,采用低压氢化,直接碱性转位得对异丙基环己酸,并用三氯化磷酰氯化后与苯丙氨酸甲酯缩合制得那格列奈,总收率50.76%。 |
| 关键词：那格列奈; 药物; 合成 |
| 中图分类号：R977.1+5 文献标识码：A 文章编号：1009-9212(2006)03-0019-02 |
|
| Synthesis of Antidiabetic Drug Nateglinide |
| DENG Yan;JIANG Huan-mei;XIE Wei-yue;TAO De-liang(Key Laboratory of Green Packaging and Biological Nanotechnology of Hunan Province;Hunan University of Technology;Zhuzhou 412008;China;Hunan Light Industry Research Institute;Changsha 410015; China) |
| Abstract：Nateglinide is a kind of new antidiabetic drug,which has a wide market prospect.In view of the present problems in the synthesis of nateglinide,the optimum synthesis conditions such as reaction time,temperature and reagent,etc were investigated and improved.Nateglinide was synthesized from 4-isopropylbenzonic acid as starting material through low-pressure catalytic hydrogenation,alkalescence displacement and condensation and the total yield was 50.76%. |
| Key words：nateglinide; drug; synthesis |
|
收稿日期：2006-02-17
|
| 阅读全文 |
|