| 第 36 卷第 4 期 |  | Vol. 36 No. 4 | | 2006 年 8 月 | Aug 2006 |
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所属栏目：有机合成原料
(Z)-4-氯-2-羟亚胺基乙酰乙酸乙酯的合成 |
| 程清蓉; 刘志雄; 李翔; 喻宗沅(武汉工程大学化工与制药学院湖北省新型反应器与绿色化学工艺重点实验室; 吉首大学化学化工学院; 湖北省化学研究院; 湖北武汉; 湖南吉首) |
| 摘 要：采用4-氯乙酰乙酸乙酯为原料,对(Z)-4-氯-2-羟亚胺基乙酰乙酸乙酯的合成条件进行了研究,确定了优化条件:反应温度5℃、反应时间4h、亚硝酸乙酯气体与4-氯乙酰乙酯的摩尔比n(ONOC2H5)∶n(ClCH2COCH2CO2C2H5)=1.4∶1。优化条件下产物收率约96%。 |
| 关键词：4-氯乙酰乙酸乙酯; （Z）-4-氯-2-羟亚胺基乙酰乙酸乙酯; 肟化反应; 合成 |
| 中图分类号：TQ225.26 文献标识码：A 文章编号：1009-9212(2006)04-0054-03 |
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| Synthesis of Ethyl 4-Chloro-3-oxo-2-(syn)-hydroxyiminoacetate |
| CHENG Qing-rong;LIU Zhi-xiong;LI Xiang;YU Zong-yuan(School of Chemical Engineering and Pharmacy;College of Chemistry and Chemical Engineering;Jishou University;Hubei Research Institute of Chemistry) |
| Abstract：Synthetic technology of ethyl 4-chloro-3-oxo-2-(syn)-hydroxy-iminoacetate was studied using ethyl 4-haloacetoacetates as raw material. The optimal conditions for the reaction were obtained as following:reaction time 4 h,reaction temperature 5℃ and the molar ratio of reactants (ONOC2H5 : ClCH2COCH2CO2C2H5)1.4 : 1. Under the optimal conditions,the yield of ethyl 4-chloro-3-oxo-2- (syn) -hydroxyiminoacetate was about 96%. |
| Key words：ethyl 4-haloacetoacetates; ethyl 4-chloro-3-oxo-2-（syn）-hydroxyiminoacetate; oximation; synthesis |
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收稿日期：2006-03-31
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