| 第 36 卷第 4 期 |  | Vol. 36 No. 4 | | 2006 年 8 月 | Aug 2006 |
|
所属栏目：农药及中间体
粉唑醇的合成 |
| 曹伟锋; 廖道华; 雷子蕙(华东理工大学制药工程系) |
| 摘 要：粉唑醇是用于植物叶片和穗的广谱杀菌剂,对谷物白粉病、云形病、叶斑病和锈病都有效。本文以邻氟溴苯为原料经格氏反应合成1-(2-氟苯基)-1-(4-氟苯基)-2-氯乙醇,然后与1,2,4-三唑钠盐反应得到标题化合物。总收率达59%,含量94.5%。 |
| 关键词：杀菌剂; 粉唑醇; 氯乙醇; 格氏反应; 邻氟溴苯; 合成 |
| 中图分类号：TQ455.4+7 文献标识码：A 文章编号：1009-9212(2006)04-0033-02 |
|
| Synthesis of Fungicide Flutriafol |
| CAO Wei-feng. LIAO Dao-hua; LEI Zi-hui （Pharmaceutical Department of East China University of Science and Technology; Shanghai 200237; China） |
| Abstract：Flutriafol was a kind of broad-spectrum fungicide that could be used to control effectively cereal powdery mildew,cloud disease,leaf spot disease and rust disease. 1-o-fluorophenyl-1-p-fluorophenyl-2-chloroethanol was prepared through Grignard reaction starting with 2-fluorobenzyl bromide,and then reacted with sodium triazol to give the title product flutriafol. The total yield and purity were 59% and 94.5%,respectively. |
| Key words：fungicide; flutriafol; ethanolyl chloride; Grignard reaction; o-fluorobenzyl bromide; synthesis |
|
收稿日期：2006-03-16
|
| 阅读全文 |
|