第 36 卷第 4 期 Vol. 36 No. 4 2006 年 8 月 Aug 2006

所属栏目：医药及中间体 2,3-二氯苯甲酸的合成研究

廖齐; 邓洪(中南林业科技大学理学院; 湖南株洲)

摘　要：2,3-二氯苯甲酸是合成特效抗癫痫药拉莫三嗪及其它治疗中枢神经紊乱药物的重要中间体。笔者用2,3-二氯苯胺经重氮化、迈尔瓦音反应制得2,3-二氯苯甲醛,再经高锰酸钾氧化制得2,3-二氯苯甲酸,总收率45%。对各步反应的操作及产品的纯化方法进行了研究。

关键词：2; 3-二氯苯甲酸; 3-二氯苯甲醛; 抗癫痫; 拉莫三嗪; 中间体; 合成

中图分类号：TQ245.3　　文献标识码：A　　文章编号：1009-9212(2006)04-0018-03

Synthesis of 2,3-Dichlorobenzoic Acid

LIAO Qi; DENG Hong （Department of Chemistry; Central South University of Forestry and Technology; Zhuzhou 412006; China）

Abstract：2,3-Dichlorobenzoic acid is the key intermediate for antiepileptic drug lamotrigine and the other medicine for the treatment of central nervous system (CNS)disorders and disease. 2,3-Dichlorobenzoic acid was prepared through diazotization and Meerwein reaction to give 2,3-dichlorobenzaldehyde from 2,3-dichloroaniline and followed by oxidation with potassium permanganate,and the overall yield was 45%. In addition,each operation of the reactions and purification was also studied .

Key words：2; 3-dichlorobenzoic acid; 3-dichlorobenzaldehyde; antiepileptic; lamotigine; intermediate; synthesis

基金项目：中南林学院引进高层次人才科研基金项目(0113)

收稿日期：2006-06-05

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