第 36 卷第 5 期 Vol. 36 No. 5 2006 年 10 月 Oct 2006

所属栏目：农药及中间体 2-巯基-3-苄氧基吡啶的合成

皮红军; 廖道华; 董捷; 王宏健; 楼江松(华东理工大学制药工程系)

摘　要：报道了超高效除草剂三氟啶磺隆的中间体2-巯基-3-苄氧基吡啶的合成方法。首先以2-氯-3-羟基吡啶(2)为原料,与溴化苄(3)在丙酮中反应制备2-氯-3-苄氧基吡啶(4);化合物4再与硫脲在无水乙醇反应得到2-巯基-3-苄氧基吡啶。总收率75.61%。

关键词：除草剂; 三氟啶磺隆; 2-巯基-3-苄氧基吡啶; 2-氯-3-羟基吡啶

中图分类号：TQ457.2　　文献标识码：A　　文章编号：1009-9212(2006)05-0047-03

Synthesis of 2-Mercapto-3-benzyloxypyridine

PI Hong-jun; LIAO Dao-hua; DONG Jie; WANG Hong-jian; LOU Jiang-song（College of Chemistry and Pharmaceutical Engineering; East China University of Science and Technology; Shanghai 200237; China）

Abstract：2-Mercapto-3-benzyloxypyridine(1)was an important intermediate of herbicide trifloxysulfuron.A new practical synthesis method of 2-mercapto-3-benzyloxypyridine(1)was described in the paper.2-Chloro-3-hydroxylpyridine was treated with 1.0 equiv.of benzyl bromide in acetone to form 2-chloro-3-benzyloxypyridine(4)in 97% yield.The compound 4 then reacted with 1.2 equiv.of thiourea in anhydrous ethanol to produce 2-mercapto-3-benzyloxypyridine(1)in 77.95% yield.The total yield of the product was 75.61%.

Key words：herbicide; trifloxysulfuron; 2-mercapto-3-benzyloxypyridine; 2-chloro-3-hydroxylpyridine; synthesis

收稿日期：2006-06-28

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