| 第 36 卷第 5 期 |  | Vol. 36 No. 5 | | 2006 年 10 月 | Oct 2006 |
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所属栏目：医药及中间体
1-氮杂-2-甲氧基-1-环庚烯的无溶剂合成 |
| 胡俐萍; 周芸; 徐满才(湖南师范大学化学化工学院; 湖南长沙) |
| 摘 要：以己内酰胺和硫酸二甲酯为原料,在无溶剂条件下合成了1-氮杂-2-甲氧基-1-环庚烯,考察了反应时间、反应温度、反应物配比等对反应收率的影响。结果表明:当反应物n(己内酰胺)∶n(硫酸二甲酯)=1∶1时,80℃反应2h,反应生成1-氮杂-2-甲氧基-1-环庚烯己内酰胺的收率72.3%。 |
| 关键词：己内酰胺; 硫酸二甲酯; 甲基化; 无溶剂合成 |
| 中图分类号：TQ463+.26 文献标识码：A 文章编号：1009-9212(2006)05-0030-02 |
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| Solvent-free Synthesis of 1-Aza-2-methoxy-1-cyccloheptene |
| HU Li-Ping; ZHOU Yun; XU Man-cai（College of Chemistry and Chemical Engineering; Hunan Normal University; Changsha 410001; China） |
| Abstract：1-Aza-2-methoxy-1-cyccloheptene was synthesized by reaction of caprolactam and dimethylsulfate without solvents.Effect of reaction time,reaction temperature and proportion of reactants on the yield of 1-aza-2-methoxy-1-cyccloheptene was investigated.Yield of 1-aza-2-methoxy-1-cyccloheptene reached 72.3% when the molar ratio of caprolactam to dimethylsulfate was 1∶1 and reacted at 80℃ for 2 h. |
| Key words：caprolactam; dimethyl sulfate; methylation; solvent-free synthesis |
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收稿日期：2006-08-27
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