| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所属栏目：其它
正交试验法研究反丁烯二酸二甲酯制备的工艺条件 |
| 张明; 朱文明(常州工程职业技术学院应用化学系; 江苏常州) |
| 摘 要：通过正交试验的方法,用马来酸酐和甲醇为原料制备反丁烯二酸二甲酯,考察了醇酸比、异构化温度、酯化时间和催化剂用量对收率的影响,确定了优化反应条件为:n(醇)∶n(酸酐)=121∶,异构化温度为100℃,回流反应6h,n(马来酸酐)n∶(磷酸)=8∶1。优化条件下可获得理想的实验结果,并经分析得到了验证。 |
| 关键词：正交试验法; 反丁烯二酸二甲酯; 制备; 反应条件 |
| 中图分类号：TQ225.2 文献标识码：A 文章编号：1009-9212(2006)06-0071-02 |
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| Synthesis of Dimethyl Fumarate with Orthogonal Test |
| ZHANG Ming; ZHU Wen-ming; （Applied Chemistry Department; Changzhou Institute of Engineering Technology; Changzhou 213164; China） |
| Abstract：Synthesis of dimethyl fumarate was carried out via orthogonal test using maleic anhydride and methanol as starting materials in this paper.The factors that affected the yield of product such as the mole ratio of maleic anhydride to methanol,isomerization temperature,esterification time and the amount of catalysts were investigated.The optimized reaction conditions were obtained as follows: the mole ratio of maleic anhydride to methanol was 12 ∶ 1,isomerization temperature was 100℃,the reaction time was 6 ho... |
| Key words：orthogonal test; dimethyl fumarate; synthesize; reaction conditions |
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收稿日期：2006-08-22
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