| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所属栏目：农药及中间体
2,4-二氯苯并噻唑的合成研究 |
| 许标; 兰支利(湖南师范大学; 湖南长沙; 长沙医学院; 410219) |
| 摘 要：以2-氨基-4-氯苯并噻唑为原料,在酸性条件下与亚硝酸钠反应,再水解生成2,4-二氯苯并噻唑。探讨了亚硝酸钠的用量、反应温度和反应时间3个因素对产物收率的影响,优化了合成工艺。在优化条件下,产品收率为91.9%,纯度达98.6%。 |
| 关键词：2-氨基-4-氯苯并噻唑; 亚硝酸钠; 重氮化 |
| 中图分类号：O626.25 文献标识码：A 文章编号：1009-9212(2006)06-0035-02 |
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| Synthesis of 2,4-Dichlorbenzothiazole |
| XU Biao1; 2; LAN Zhi-li1（1.Hunan Normal Univesity; Changsha 410001; China; 2.Changsha Medical College; Changsha 410229; China） |
| Abstract：2,4-Dichlorbenzothiazole was prepared from 2-amino-4-chlorbenzothiazole through diazotization and hydrolysis.The amount of sodium nitrite,reaction temperature and time were the main effective factors,and the optimum synthesis conditions were obtained.The yield and purity of the product reached 91.9% and 98.6%,respectively,under the optimal conditions. |
| Key words：2-amino-4-chlorbenzothiazole; sodium nitrite; diazotization reaction |
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收稿日期：2006-08-26
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