| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所属栏目：农药及中间体
对乙氧基苯乙酸的合成研究 |
| 丛杉; 王涛; 沈德隆; 孙娜波(浙江工业大学化学工程与材料学院; 浙江新迪国际食品有限公司; 浙江杭州) |
| 摘 要：以对羟基苯乙酸为原料,分别采用溴乙烷和硫酸二乙酯为醚化试剂,经Williamson醚化合成了对乙氧基苯乙酸。通过正交实验得出两条路线的较优合成条件:溴乙烷法中,n(对羟基苯乙酸)n∶(溴乙烷)=11∶.6,反应温度68℃,反应时间5h,收率85%左右;硫酸二乙酯法中,n(对羟基苯乙酸)n∶(硫酸二乙酯)n∶(氢氧化钠)=1∶2.5∶2.4,反应温度80℃,收率在90%以上。 |
| 关键词：对乙氧基苯乙酸; 溴乙烷; 硫酸二乙酯; 合成 |
| 中图分类号：TQ245.1+3 文献标识码：A 文章编号：1009-9212(2006)06-0032-03 |
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| Synthesis of 4-Ethoxyphenylacetic Acid |
| CONG Shan1; WANG Tao2; SHEN De-long1; SUN Na-bo1（1.Institute of Pesticide; Zhejiang University of Technology; Hangzhou 310032; China; 2.Zhejiang Xindi International Food Co.Ltd; Hangzhou 310006; China） |
| Abstract：4-Ethoxyphenylacetic acid was synthesized from 4-hydroxyphenylacetic acid by the Williamson etherization reaction.Ethyl bromide and diethyl sulfate were used as etherization reagents,respectively.By experiments utilizing an orthogonal design,optimum synthesis conditions were obtained as follows: in the ethyl bromide route,the molar ratio of 4-hydroxyphenylacetic acid to ethyl bromide was 1 ∶ 1.6,the reaction temperature was 68℃,the reaction time was 5 h and the yield was about 85%.In the diethyl sulfate rou... |
| Key words：4-ethoxyphenylacetic acid; ethyl bromide; diethyl sulfate; synthesis |
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收稿日期：2006-10-18
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