| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所属栏目：农药及中间体
甲硫嘧磺隆原药的合成工艺研究 |
| 庞怀林; 杨剑波; 黄明智; 尹笃林(湖南化工研究院国家农药创制工程技术研究中心; 湖南师范大学化学化工学院; 湖南长沙) |
| 摘 要：甲硫嘧磺隆(C9908)是湖南化工研究院对磺酰脲类化合物进行结构修饰而得到的新除草剂。探讨了以2-氨基-4-甲氧基-6-甲硫基嘧啶(AOTP)和2-甲酸甲酯苯磺酰异氰酸酯(MCBI)为原料合成标题化合物的方法,对影响反应的主要因素进行了研究,获得了优化反应条件:n(AOTP)n∶(MCBI)=11∶.75、温度60～70℃、时间1.5h。优化条件下,收率高于93%,产品含量高于96%。 |
| 关键词：甲硫嘧磺隆; 2-氨基-4-甲氧基-6-甲硫基嘧啶; 除草剂; 合成 |
| 中图分类号：S482.4 文献标识码：A 文章编号：1009-9212(2006)06-0026-03 |
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| Synthesis of Sulfonylurea Herbicide 2-[[[[(4-Methoxy-6-methylthio-2-pyrimidinyl) amino]carbonyl]amino]sulfonyl]Benzoic Acid Methyl Ester |
| PANG Huai-lin;YANG Jian-bo;HUANG Ming-zhi;YIN Du-lin(National Engineering Research Center for Agrochemicals;Hunan Research Institute of Chemical Industry;College of Chemistry and Chemical Engineering;Hunan Normal University) |
| Abstract：2-[[[[(4-methoxy-6-methylthio-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]Benzoic acid methyl ester(C9908) was a novel sulfonylurea herbicide with high herbicidal activity that discovered by Hunan Research Institute of Chemical Industry The herbicide C9908 was synthesized from 2-amino-4-methoxy-6-methylthiopyrimidine(AOTP)and 2-methoxycarbonyl-benzenesulfonyl isocyanate(MCBI).The major factors which influenced the reaction were studied,and the optimum process conditions were obtained as follow:reaction temp... |
| Key words：2-[[[[（4-methoxy-6-methylthio-2-pyrimidinyl）amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester; 2-amino-4-methoxy-6-methylthiopyrimidine; herbicide; synthesis |
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基金项目：“十五”国家科技攻关计划资助项目(2001BA308A02-11、2004BA308A24-4)
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收稿日期：2006-10-08
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