| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所属栏目：医药及中间体
微波辐射法合成5-取代四氮唑衍生物 |
| 姜凤超; 王静(华中科技大学同济医学院药学院; 湖北武汉) |
| 摘 要：研究了将氰化物与叠氮化合物在微波辐射条件下反应,得到5-取代四氮唑合成了4个5-芳香取代的四氮唑衍生物,所得产物经IR,NMR鉴定。与原有方法相比,微波辐射法反应时间大大缩短(由几十小时缩短为几十分钟),还具有收率较高、后处理简单等优点。 |
| 关键词：微波辐射; 四氮唑衍生物; 合成 |
| 中图分类号：O623.626 文献标识码：A 文章编号：1009-9212(2006)06-0022-04 |
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| Synthesis of 5-Substituted Tetrazole Derivatives by Microwave Radiation Method |
| JIANG Feng-chao; WANG Jing（School of Pharmacy; Tongji Medical College of HUST; Wuhan 430030; China） |
| Abstract：Tetrazole derivatives have been extensively used in medicine,but there were some disadvantages in its classic synthetic method such as long reaction time(tens hours,even several days),low yield and the troublesome after-treatment.Using microwave irradiation method four 5-substitued tetrazole derivatives were prepared in 30 minutes,and the optimum reaction condition was obtained.The target compounds were identical with the document. |
| Key words：microwave radiation; tetrazole derivatives; synthesis |
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收稿日期：2006-09-28
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