第 36 卷第 6 期 Vol. 36 No. 6 2006 年 12 月 Dec 2006

所属栏目：医药及中间体 5-羟基色满的合成

黄二芳; 朱丽丹; 孙蕊; 金丽萍; 胡春(沈阳药科大学制药工程学院; 辽宁沈阳)

摘　要：以2',6'-二羟基苯乙酮为起始原料,在钠催化下和甲酸乙酯缩合制得5-羟基-4-色酮,然后催化氢化还原得到5-羟基-4-色满酮,最后用锌汞齐还原制得5-羟基色满。所设计的5-羟基色满合成路线总收率能达到37%,是合成5-羟基色满的新路线。

关键词：药物化学; 5-羟基色满; 5-羟基-4-色酮; 5-羟基-4-色满酮; 合成; Clemmensen还原; 催化氢化

中图分类号：TQ225.2　　文献标识码：A　　文章编号：1009-9212(2006)06-0020-02

Study on Synthesis of 5-Hydroxychroman

HUANG Er-fang; ZHU Li-dan; SUN Rui; JIN Li-ping; HU Chun; （School of Pharmaceutical Engineering; Shenyang Pharmaceutical University; Shenyang 110016; China）

Abstract：5-Hydroxychroman was prepared by Clemmensen reduction from 5-hydroxy-4-chromanone,whereas 5-hydroxy-4-chromanone was prepared by catalytic hydrogenation from 5-hydroxy-4-chromone which was prepared from2',6'-dihydroxyacetophenone.5-Hydroxychroman can be synthesized with total yield of 37% according to the novel procedure reported in this paper.

Key words：medicinal chemistry; 5-hydroxychroman; 5-hydroxy-4-chromone; 5-hydroxy-4-chromanone; synthesis; clemmensen reduction; catalytic hydrogenation

基金项目：国家自然科学基金资助项目(20472053)

收稿日期：2006-10-29

阅读全文