| 第 36 卷第 6 期 |  | Vol. 36 No. 6 | | 2006 年 12 月 | Dec 2006 |
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所属栏目：医药及中间体
新型喹唑啉化合物的合成与生物活性 |
| 薛伟; 宋宝安; 杨松; 胡德禹; 刘刚; 刘平生; 张培权; 金林红; 张素梅(贵州大学精细化工研究开发中心; 贵州贵阳; 教育部绿色农药与农业生物工程重点实验室) |
| 摘 要：设计并合成4类新型喹唑啉化合物,进行医药和农药的联合筛选,生物活性测试表明部分新化合物具有较好的生物活性。 |
| 关键词：喹唑啉; 中间体; 生物活性 |
| 中图分类号：O626 文献标识码：A 文章编号：1009-9212(2006)06-0016-04 |
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| Synthesis and Application of Novel Intermediate of Quinazoline Compounds |
| XUE Wei;SONG Bao-an;YANG Song;HU De-yu;LIU Gang;LIU Ping-sheng;ZHANG Pei-quan;JIN Lin-hong;ZHANG Su-mei(Research and Development Center for Fine Chemicals of Guizhou University;Key Laboratory of Green Pesticide and Agriculture Bioengineering... |
| Abstract：Four kinds of novel quinazoline compounds were designed and synthesized for the joint development of medicine and pesticides in this paper.The bioassay results showed that some new compounds had good inhibitory activity against growth of crop pathogenic fungi and ERK 1/2 phosphorylation of PC3 cells. |
| Key words：quinazoline; intermediate; bioactivity |
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基金项目：国家重点基础研究发展计划“973”计划(2003CB114404);国家自然科学基金(20442003,20562003);贵州省省长资金项目资助
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收稿日期：2006-08-31
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