| 第 37 卷第 2 期 |  | Vol. 37 No. 2 | | 2007 年 4 月 | Apr 2007 |
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所属栏目：安全与环保
尼龙树脂高分子季铵盐的制备及其不溶性杀菌灭菌活性 |
| 王晓丹1，2，李 盛1，2，邱树毅1，2，3，何 敏3，何 力3
（1.贵州省发酵工程与生物制药重点实验室，贵州 贵阳 550003；2.贵州大学 化学工程学院，贵州 贵阳 550003；3.贵州省材料创新基地，贵州 贵阳 550000） |
| 摘 要：尼龙6用4-溴丁酰氯活化，再与高分子聚乙烯亚胺（PEI）在有机溶剂中进行反应，使PEI共价接枝在载体上，然后用卤代烷对接枝在尼龙6上的PEI进行烷基化反应，使其形成具有杀菌功能的高分子季铵盐，制备出尼龙树脂固定化的高分子抗菌杀生剂。高分子抗菌杀生剂的抗菌灭藻性能的检测结果表明，作用30 min对贵阳市雅河水中的异养菌、氨化细菌、反硝化细菌、亚硝化细菌的杀菌率在90%以上，真菌、硫酸盐还原菌的杀菌率在85%以上；对黑曲霉的杀菌率在84%，其作用24 h可将小球藻基本杀灭。 |
| 关键词：尼龙；季铵盐；杀菌剂 |
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| Preparation of a Novel Biocide Using Poly Quaternary Ammonium Salt Grafted Nylon |
| WANG Xiao-dan1，2，LI Sheng1，2，QIU Shu-yi1，2，3，HE Min3，HE Li3
（1. Guizhou Province Key Laboratory of Fermentation Engineering and Biopharmacy；2. Guizhou University；3. Guizhou Province Base of Material Innovation，Guiyang 550000，China） |
| Abstract：The nylon was activated with organic functional groups，and after that reacted with high-molecular-weight polyethylenimine（PEI）in the organic soleent. PEI was grafted covalently on the surface of nylon. The PEI grafted on the surface of nylon was modified by the alkyl halide such as bromohexane and iodomethane，to give high-molecular-weight antimicrobial quaternary ammonium salts. The bioassay results showed that the quaternary ammonium salt had a good intihtion against typical microorganisms such as heterotrophic bacteria，ammonifying bacteria，denitrifying bacteria and nitrosation bacteria with its inhibition rate was above 90%. Inhibition of the quaternary ammonium salt to fungi and sulfate reducting bacteria was above 85% after 30 min. Inhibition of the quaternary ammonium salt to black mold was about 84% after 30 min，and the to algae was totally inhibited after 24 h. |
| Key words：nylon；quaternary ammonium salts；biocide |
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基金项目：贵州省年度攻关材料专项基金资助项目（黔科合GY（2005）3038号），贵州省优秀科技和教育人才省长基金资助项目（黔省专合（2005）358号），贵州省优秀科技人才培养对象专项基金资助项目（黔科合人字（2005）0524号）。
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作者简介：王晓丹（1980-），女，辽宁大连人，硕士研究生，研究方向：抗菌材料。（Email：wangxiaodan0516@126.com）
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联 系 人：邱树毅，教授。研究方向：抗菌材料。（Email：syqiu@gzu.edu.cn）
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收稿日期：2006-11-23
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