| 第 37 卷第 6 期 |  | Vol. 37 No. 6 | | 2007 年 12 月 | Dec 2007 |
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所属栏目：农药及中间体
丙酮肟法合成乙氧基胺盐酸盐 |
| 潘忠稳，李玉喜，夏 岚
（安徽大学 化学化工学院，安徽 合肥 230039） |
| 摘 要：通过三步反应合成乙氧基胺盐酸盐，采用盐酸羟胺和丙酮反应制备丙酮肟，经硫酸二乙酯乙基化、盐酸水解合成乙氧基胺盐酸盐。实验考察了反应温度、催化剂量、反应时间对乙基化反应的影响。结果表明：在无催化剂条件下，25℃下反应6 h，O-乙基丙酮肟收率87.6%（以丙酮肟计），产品总收率为66.7%（以盐酸羟胺计）。 |
| 关键词：丙酮肟；O-乙基丙酮肟；乙氧基胺盐酸盐；合成 |
| 中图分类号：O625.6 文献标识码：A 文章编号：1009-9212（2007）06- 0017-02 |
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| Synthesis of Ethoxyamine Hydrochloride via Acetoxime |
| PAN Zhong-wen，LI Yu-xi，XIA Lan
（School of Chemistry & Chemical Engineering，Anhui University，Hefei 230039，China） |
| Abstract：Ethylamine hydrochloride as pesticide and pharmaceutical intermediates was synthesized through three step reactions. Hydroxylamine hydrochloride was contacted with acetone to give acetoxime then acetoxime was alkylated by diethyl sulfate to form O-ethylacetoxime，and finally，O-ethylacetoxime was hydrolyzed by hydrochloric acid to obtain ethylamine hydrochloride . The process of the reaction was optimized as follow：acetoxime reacted with diethyl sulfate for 6 h at 25℃ without catalyst to give O-ethylacetoxime with 87.6% of yield baseed on acetoxime. The total yield of product was 66.7% based on hydroxylamine hydrochloride. |
| Key words：alkylamine hydrochloride；acetoxime；O-ethylacetoxime；synthesis |
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作者简介：潘忠稳（1963-），男，安徽合肥人，高级工程师，硕士，从事农药及精细化学品的合成、分析研究。（E-mail：ahpzw@163.com）
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收稿日期：2007-09-13
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